Bilateral Intracranial Beta Activity During Forced and Spontaneous Movements in a 6-OHDA Hemi-PD Rat Model

Cortico-basal ganglia beta oscillations (13–30 Hz) are assumed to be involved in motor impairments Parkinson’s Disease (PD), especially bradykinesia and rigidity. Various studies have utilized the unilateral 6-hydroxydopamine (6-OHDA) rat PD model further investigate test novel treatments. However, a detailed behavioral electrophysiological characterization of model, including analyses popular treatments such as DBS, has not been documented literature. We hence challenged 6-OHDA hemi-PD with series experiments (i.e., cylinder test, open field rotarod test) aimed at assessing impairments, analyzing effects Deep Brain Stimulation (DBS), identifying under which conditions excessive occur. found that rats presented an impaired performance all compared sham group, DBS could improve their overall performance. Across behaviors, power high band was observed important biomarker for it showed differences between healthy lesioned hemispheres 6-OHDA-lesioned rats. This shows accurately represents many symptoms makes useful tool pre-clinical testing new when low β (13–21 (21–30 frequency bands considered separately.